PD CEN ISO/TS 23973:2021

What is ISO 23973 about? 

ISO 23973 discusses liquid chromatography at critical conditions (LCCC).  

ISO 23973 specifies a valid method for the separation of chemically heterogeneous polyethylene oxide (PEO) mixtures and the determination of the number and content of the chemically heterogeneous species in the overall sample. 

The method presented under ISO 23973 serves as a technical guideline for learning the principle of “critical chromatography” on a validated system. 

Note: The method presented in ISO 23973 stated system parameters is not applicable for other polymer classes, due to the diversity of the interactions between the polymer/mobile phase/stationary phase and the number of separation systems that are therefore available. 

Who is ISO 23973 for? 

ISO 23973 on Liquid chromatography at critical conditions (LCCC) is relevant to: 

• Manufacturing of liquid chromatography 
• Companies dealing with chemical heterogeneity of polyethylene oxides 
• Retailer and suppliers of liquid chromatography 

Why should you use ISO 23973? 

Liquid chromatography at critical conditions is a special form of liquid chromatography of polymers at the point of adsorption, where chemically and structurally identical polymers with a certain repeat unit elute independently of the molar mass at the same retention time.  

ISO 23973 assists in LCCC by providing an efficient method for chemical heterogeneity of polyethylene oxides and thus, is useful for building an efficient LCCC. 

As a buyer of ISO 23973, you can use the information regarding the chemical heterogeneity of polyethylene oxide by testing the product, analysis of the validation kit, sample preparation, detectors, colour temperature control, etc. which helps in the safety and manufacturing of liquid chromatography at critical conditions. 

What’s changed since the last update? 

PD CEN ISO/TS 23973:2021 supersedes PD ISO/TS 23973:2020, which is withdrawn.